submersion style recording chamber (Fine Science Tools)
90
Structured Review
Fine Science Tools
submersion style recording chamber
Submersion Style Recording Chamber, supplied by Fine Science Tools, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/submersion+style+recording+chamber/submersion+style+recording+chamber/pm21619887-131-18-22
Average 90 stars, based on 1 article reviews
Submersion Style Recording Chamber, supplied by Fine Science Tools, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/submersion+style+recording+chamber/submersion+style+recording+chamber/pm21619887-131-18-22
Average 90 stars, based on 1 article reviews
submersion style recording chamber - by Bioz Stars,
2026-10
90/100 stars
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other:Article Title: The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents. Article Snippet: Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving cognitive dysfunction in Alzheimer’s disease.. PF-04447943, (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one), a recently described PDE9 inhibitor, was found to have high affinity (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1e8 and 10e11.. PF-04447943 significantly increased neurite outgrowth and synapse formation (as indicated by increased synapsin 1 expression) in cultured hippocampal neurons at low (30e100 nM) but not high (300e1000 nM) concentrations. |